Exercise Training Improves Brachial Artery Endothelial Function, but Does Not Alter Inflammatory Biomarkers in Patients with Peripheral Artery Disease: a Systematic Review and Meta-analysis

• Published in: Journal of cardiovascular translational research 2024-06, Vol.17 (3), p.585-597
• Main Authors: Lee, Junghoon, Zarezadehmehrizi, Aliasghar, LaVoy, Emily C., Markofski, Melissa M., Park, Yoonjung
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - blood; Biomedical Engineering and Bioengineering; Biomedicine; Brachial Artery - physiopathology; Cardiology; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Exercise Therapy; Female; Human Genetics; Humans; Inflammation - blood; Inflammation - diagnosis; Inflammation - physiopathology; Inflammation Mediators - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - physiopathology; Peripheral Arterial Disease - therapy; Recovery of Function; Review; Time Factors; Treatment Outcome; Vasodilation
• ISSN: 1937-5387; 1937-5395; 1937-5395
• DOI: 10.1007/s12265-023-10451-0

The study aimed to systematically review the effects of exercise training (EX) on brachial artery flow-mediated dilation (FMD) and inflammatory biomarkers in patients with peripheral artery disease (PAD). Five electronic databases were searched: (i) patients with PAD aged ≥ 18; (ii) structured EX ≥ 2 weeks; (iii) measured brachial artery FMD; and (iv) measured blood inflammatory biomarkers. Eighteen studies met the inclusion criteria. EX increased FMD but had no effect on C-reactive protein, interleukin-6, and tumor necrosis factor-α. Subgroups with moderate intensity had a greater increase in FMD than subgroups with vigorous intensity. There was no difference in effect on FMD and three inflammatory biomarkers between subgroups training for ≤ 12 weeks and > 12 weeks of EX,