Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress

• Published in: Journal of neuroimaging 2024-01, Vol.34 (1), p.152-162
• Main Authors: Han, Caleb, Waddle, Spencer, Garza, Maria, Davis, Larry T., Eisma, Jarrod J., Richerson, Wesley T., Fusco, Matthew, Chitale, Rohan, Custer, Chelsea, McKnight, Colin D., Jordan, Lori C., Donahue, Manus J.
• Format: Article
• Language: English
• Subjects: Angiography; Aspirin; Blood levels; Blood vessels; Carbon dioxide; Cerebrovascular Disorders; cerebrovascular reactivity; Choroid plexus; Choroid Plexus - diagnostic imaging; Constriction, Pathologic; CSF; Delay time; glymphatic; Humans; Hyperemia; Ischemia; Medical instruments; moyamoya; Moyamoya Disease - diagnostic imaging; neurofluid; Neuroimaging; Occlusion; Oxygenation; Regression analysis; Reserve capacity; Spatial discrimination; Spatial resolution; Stenosis; Time dependence; Variance analysis; Vascular diseases
• ISSN: 1051-2284; 1552-6569
• DOI: 10.1111/jon.13161

Background and Purpose Choroid plexus (ChP) hyperemia has been observed in patients with intracranial vasculopathy and to reduce following successful surgical revascularization. This observation may be attributable to impaired vascular reserve of the ChP or other factors, such as the ChP responding to circulating markers of stress. We extend this work to test the hypothesis that vascular reserve of the ChP is unrelated to intracranial vasculopathy. Methods We performed hypercapnic reactivity (blood oxygenation level‐dependent; echo time = 35 ms; spatial resolution = 3.5 × 3.5 × 3.5 mm, repetition time = 2000 ms) and catheter angiography assessments of ChP reserve capacity and vascular patency in moyamoya patients (n = 53) with and without prior surgical revascularization. Time regression analyses quantified maximum cerebrovascular reactivity and reactivity delay time in ChP and cortical flow territories of major intracranial vessels with steno‐occlusion graded as