Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients

Purpose Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant arrhythmias. This study aims to evaluate comprehensive tissue characterization of the PM by cardiovascular magnetic resonance (CMR) imaging...

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Bibliographic Details
Published in:The international journal of cardiovascular imaging 2024-02, Vol.40 (2), p.213-224
Main Authors: Spampinato, Ricardo A., Marin-Cuartas, Mateo, van Kampen, Antonia, Fahr, Florian, Sieg, Franz, Strotdrees, Elfriede, Jahnke, Cosima, Klaeske, Kristin, Wiesner, Karoline, Morningstar, Jordan E., Nagata, Yasufumi, Izquierdo-Garcia, David, Dieterlen, Maja-Theresa, Norris, Russell A., Levine, Robert A., Paetsch, Ingo, Borger, Michael A.
Format: Article
Language:English
Subjects:
Biopsy
Blood
Cardiac Imaging
Cardiology
Fibrosis
Gadolinium
Heart
Imaging
Magnetic resonance
Magnetic resonance imaging
Mapping
Medical imaging
Medicine
Medicine & Public Health
Mitral valve
Mitral valve prolapse
Muscles
Original Paper
Radiology
Regurgitation
Surgery
Ventricle
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Summary:Purpose Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant arrhythmias. This study aims to evaluate comprehensive tissue characterization of the PM by cardiovascular magnetic resonance (CMR) imaging and its association with LV fibrosis observed by intraoperative biopsies. Methods MVP patients with indication for surgery due to severe mitral regurgitation (n = 19) underwent a preoperative CMR with characterization of the PM: dark-appearance on cine, T1 mapping, conventional bright blood (BB) and dark blood (DB) late gadolinium enhancement (LGE). CMR T1 mapping was performed on 21 healthy volunteers as controls. LV inferobasal myocardial biopsies were obtained in MVP patients and compared to CMR findings. Results MVP patients (54 ± 10 years old, 14 male) had a dark-appearance of the PM with higher native T1 and extracellular volume (ECV) values compared with healthy volunteers (1096 ± 78ms vs. 994 ± 54ms and 33.9 ± 5.6% vs. 25.9 ± 3.1%, respectively, p 
ISSN:1875-8312
1569-5794
1875-8312
1573-0743
DOI:10.1007/s10554-023-02985-w