Biochemical aspects of the inflammatory process: A narrative review

Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physiological changes that trigger the release of pro-in...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2023-12, Vol.168, p.115764-115764, Article 115764
Main Authors: Soares, Caroline Leal Rodrigues, Wilairatana, Polrat, Silva, Larissa Rodrigues, Moreira, Polyanna Silva, Vilar Barbosa, Nayana Maria Medeiros, da Silva, Pablo Rayff, Coutinho, Henrique Douglas Melo, de Menezes, Irwin Rose Alencar, Felipe, Cícero Francisco Bezerra
Format: Article
Language:English
Subjects:
Inflammation
Inflammatory diseases
Inflammatory mediators
Inflammatory process
Review
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Summary:Inflammation is a protective response of the body potentially caused by microbial, viral, or fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of inflammation are consequences of immunological, biochemical, and physiological changes that trigger the release of pro-inflammatory chemical mediators at the local of the injured site thus, increasing blood flow, vascular permeability, and leukocyte recruitment. The aim of this study is to give an overview of the inflammatory process, focusing on chemical mediators. The literature review was based on a search of journals published between the years 2009 and 2023, regarding the role of major chemical mediators in the inflammatory process and current studies in pathogenesis, diagnosis, and therapy. Some of the recent contributions in the study of inflammatory pathologies and their mediators, including cytokines and chemokines, the kinin system, free radicals, nitric oxide, histamine, cell adhesion molecules, leukotrienes, prostaglandins and the complement system and their role in human health and chronic diseases.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.115764