FXR agonists INT‐787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet‐induced ob/ob mouse model of NASH

Background and Aims We have previously shown in a model of hepatic ischaemia/reperfusion injury that the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) restores reversion‐inducing‐cysteine‐rich protein with Kazal motifs (RECK), an inverse modulator of metalloproteases (MMPs) and inhibitor...

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Published in:	Liver international 2024-01, Vol.44 (1), p.214-227
Main Authors:	Di Pasqua, Laura G., Cagna, Marta, Palladini, Giuseppina, Croce, Anna C., Cadamuro, Massimiliano, Fabris, Luca, Perlini, Stefano, Adorini, Luciano, Ferrigno, Andrea, Vairetti, Mariapia
Format:	Article
Language:	English
Subjects:	ADAMs Agonists Alanine Alanine transaminase Animals Cadmium Cell activation Chenodeoxycholic Acid - pharmacology Collagen Collagen - metabolism Collagen - pharmacology Deposition Diet Diet, High-Fat - adverse effects Down-regulation Fatty liver FXR High fat diet Inflammation Inflammation - drug therapy Inflammation - metabolism INT‐787 Ischemia Liver Liver - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - pharmacology Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase 9 - pharmacology Mice Molecular modelling NASH Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism OCA Proteins RECK Reperfusion Steatosis
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