Comparing the effectiveness of CBT and low-frequency rTMS in reducing symptom severity and depression and improving working memory in adults with OCD: a clinical trial

This study aims to compare the effectiveness of cognitive-behavioral therapy (CBT) and low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) in reducing symptom severity and depression and improving working memory in adults with obsessive-compulsive disorder (OCD). This is a randomi...

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Bibliographic Details
Published in:International journal of neuroscience 2024-12, Vol.134 (12), p.1635-12
Main Authors: Fazeli, Arash, Zolghadriha, Ahmad, Pirzeh, Reza, Fatehi Chenar, Atefeh, Dadashi, Mohsen
Format: Article
Language:English
Subjects:
Adult
Cognitive Behavioral Therapy - methods
Depression - etiology
Depression - therapy
Female
Humans
Male
Memory, Short-Term - physiology
Middle Aged
Obsessive-Compulsive Disorder - physiopathology
Obsessive-Compulsive Disorder - therapy
Psychiatric Status Rating Scales
Severity of Illness Index
Transcranial Magnetic Stimulation - methods
Treatment Outcome
Young Adult
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Summary:This study aims to compare the effectiveness of cognitive-behavioral therapy (CBT) and low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) in reducing symptom severity and depression and improving working memory in adults with obsessive-compulsive disorder (OCD). This is a randomized clinical trial conducted on 24 adults with OCD, randomly assigned into two groups of CBT (  = 12, received CBT with exposure and response prevention (ERP) individually at 20 sessions) and rTMS (  = 12, received LF (1-Hz) rTMS over the right dorsolateral prefrontal cortex (DLPFC) at 10 sessions). They completed the Yale-Brown Obsessive Compulsive Scale, the Hamilton Depression Rating Scale, and two N-Back tasks before, immediately, and 1 month after interventions. Results showed a significant difference between the two methods in reducing the severity of OCD symptoms (   0.05). No significant difference was found between groups in any study variables 1 month after interventions. Individual CBT with ERP is superior to LF rTMS for reducing the severity of symptoms and depression in OCD patients. However, there is no difference between them in improving working memory.
ISSN:0020-7454
1563-5279
1563-5279
1543-5245
DOI:10.1080/00207454.2023.2279500