Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined pathogenic diversity 1 , 2 . Here, to deconstruct the...

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Bibliographic Details
Published in:	Nature (London) 2023-11, Vol.623 (7987), p.616-624
Main Authors:	Zhang, Fan, Jonsson, Anna Helena, Nathan, Aparna, Millard, Nghia, Curtis, Michelle, Xiao, Qian, Gutierrez-Arcelus, Maria, Apruzzese, William, Watts, Gerald F. M., Weisenfeld, Dana, Nayar, Saba, Rangel-Moreno, Javier, Meednu, Nida, Marks, Kathryne E., Mantel, Ian, Kang, Joyce B., Rumker, Laurie, Mears, Joseph, Slowikowski, Kamil, Weinand, Kathryn, Orange, Dana E., Geraldino-Pardilla, Laura, Deane, Kevin D., Tabechian, Darren, Ceponis, Arnoldas, Firestein, Gary S., Maybury, Mark, Sahbudin, Ilfita, Ben-Artzi, Ami, Mandelin, Arthur M., Nerviani, Alessandra, Lewis, Myles J., Rivellese, Felice, Pitzalis, Costantino, Hughes, Laura B., Horowitz, Diane, DiCarlo, Edward, Gravallese, Ellen M., Boyce, Brendan F., Moreland, Larry W., Goodman, Susan M., Perlman, Harris, Holers, V. Michael, Liao, Katherine P., Filer, Andrew, Bykerk, Vivian P., Wei, Kevin, Rao, Deepak A., Donlin, Laura T., Anolik, Jennifer H., Brenner, Michael B., Raychaudhuri, Soumya
Format:	Article
Language:	English
Subjects:	13/31 13/51 14/63 38/39 38/91 45/47 631/250/2520 692/699/1670/498 82/80 Arthritis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune diseases B-Lymphocytes - immunology Biopsy Cells Correlation analysis Cytokines Cytokines - metabolism Disease Fibroblasts Gene sequencing Genetic Predisposition to Disease - genetics Heterogeneity Histology Humanities and Social Sciences Humans Inflammation Inflammation - complications Inflammation - genetics Inflammation - immunology Inflammation - pathology Lymphocytes multidisciplinary Osteoarthritis Patients Phenotype Phenotypes Plasma Proteins Rheumatoid arthritis Rheumatoid synovitis Science Science (multidisciplinary) Serology Single-Cell Gene Expression Analysis Synovial Membrane - pathology T-Lymphocytes - immunology Tissues
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