The bioaccumulation and biotransformation of tetrabromobisphenol A bis (allyl ether) in common carp (Cyprinus carpio)

Tetrabromobisphenol A bis (allyl ether) (TBBPA-BAE) is an extensively used brominated flame retardant, which has raised considerable concern because of its neurotoxic and endocrine disruption effects on aquatic organisms. However, previous studies mainly focused on the parent compound before modific...

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Published in:Environmental science and pollution research international 2023-12, Vol.30 (58), p.121465-121474
Main Authors: Zhao, Jia, Zhao, Hongxia, Zhong, Zhihui, Bekele, Tadiyose Girma, Wan, Huihui, Sun, Yuming, Li, Xintong, Zhang, Xiaonuo, Li, Zhansheng
Format: Article
Language:English
Subjects:
Aquatic organisms
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bioaccumulation
Biological magnification
Biotransformation
Bromination
Carp
Cyprinus carpio
Depuration
Earth and Environmental Science
Ecotoxicology
Endocrine disruptors
Environment
Environmental Chemistry
Environmental Health
Fish
Flame retardants
Liver
Metabolites
Neurotoxicity
Research Article
Risk assessment
Tetrabromobisphenol A
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Tetrabromobisphenol A bis (allyl ether) (TBBPA-BAE) is an extensively used brominated flame retardant, which has raised considerable concern because of its neurotoxic and endocrine disruption effects on aquatic organisms. However, previous studies mainly focused on the parent compound before modification, tetrabromobisphenol A (TBBPA), and little information is available about the bioconcentration and biotransformation of TBBPA derivatives in fish. In this study, we investigated the tissue-specific uptake, elimination kinetic, and biotransformation of TBBPA-BAE in common carp ( Cyprinus carpio ). The fish were exposed to TBBPA-BAE at environmentally relevant concentrations (20 μg·L −1 ) for 28 days, followed by 14 days of depuration. The results showed TBBPA-BAE could rapidly accumulate in common carp. Among the seven tissues studied, the highest concentrations of TBBPA-BAE were observed in the liver (6.00 μg·g −1 wet weight [ww]) on day 24, while the longest residence time was observed in the kidney ( t 1 /2 values of 18.7 days). Biotransformation of TBBPA-BAE was documented in the in vivo experiments, and 14 different phase I and phase II metabolites were identified in the liver. These findings suggest the biotransformation products of TBBPA-BAE should be considered for a comprehensive risk evaluation. Graphical abstract
ISSN:1614-7499
0944-1344
1614-7499
DOI:10.1007/s11356-023-30846-5