MIB Guides: Preclinical Radiopharmaceutical Dosimetry

Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providi...

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Bibliographic Details
Published in:Molecular imaging and biology 2024-02, Vol.26 (1), p.17-28
Main Authors: Carter, Lukas M., Zanzonico, Pat B.
Format: Article
Language:English
Subjects:
2-Methylisoborneol
Animals
Diagnostic Imaging
Dosimeters
Dosimetry
Estimates
Ethical standards
Humans
Imaging
Medicine
Medicine & Public Health
Pharmaceuticals
Radiochemistry
Radioisotopes
Radiology
Radiometry - methods
Radiopharmaceuticals - therapeutic use
Software
Special Topic
Tissue Distribution
Citations: Items that this one cites
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Description
Summary:Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providing reasonable initial estimates of normal-organ doses in humans, required for clinical translation of new radiopharmaceuticals. This MIB Guide provides a basic protocol for obtaining preclinical dosimetry estimates with organ-level dosimetry software.
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-023-01868-9