The influence of stereotaxic lesions of claustrum on motor movements and behaviour in rats

• Published in: Somatosensory & motor research 2024-12, Vol.41 (4), p.264-8
• Main Authors: Seçen, Ahmet Eren, Akçalı, Didem Tuba, Dileköz, Ergin, Çağıl, Emin, Divanlıoğlu, Denizhan, Öcal, Özgür, Bolay Belen, Hayrunnisa
• Format: Article
• Language: English
• Subjects: Animals; Anxiety - etiology; Anxiety - physiopathology; Behavior, Animal - physiology; Claustrum - physiology; Claustrum - physiopathology; Male; Maze Learning - physiology; Motor Activity - physiology; Rats; Rats, Wistar; Stereotaxic Techniques
• ISSN: 0899-0220; 1369-1651; 1369-1651
• DOI: 10.1080/08990220.2023.2280563

This study aimed to expand our existing information on changes in the regulation of motor movement and behaviour by investigating the effects of unilateral and bilateral lesions on the claustrum (CL). 36 Wistar Albino adult male rats were randomly divided into six groups. An electrical lesion was created with a constant current source in the unilateral and bilateral anterior clastrum using a stereotaxic frame in rats. The lesioned groups and the control group underwent an automatic behaviour recording device such as mobilisation, freezing, eating, drinking behaviour, grooming, turning, etc. behaviour was recorded and analysed. Simultaneously, ultrasonic sounds in rats were examined with ultrasonic sound recording program. Anxiety was then reassessed with the elevated plus maze test. Data were compared with the control group. Rats were eventually sacrificed and the brain tissue was post-fixed. Histochemical examination was done and lesions' existence was confirmed. In this study, lesions of ventral of CL can cause increase in spontaneous behaviours such as freezing and rearing. And, it has been shown to cause a statistically significant change. In addition to the behavioural changes, right CL lesions have caused a significant increase in drinking behaviour associated with increased anxiety. All operated groups showed a significant decrease in clockwise and counterclockwise rotation movements. Experimental results show that CL lesions influence spontaneous behaviour which indicate the need for new studies to understand the role of CL in anxiety-depression.