Simvastatin Attenuates Areca Nut Extract-Induced Subdermal Fibrosis in Mice by Targeting TGF-β Signaling Pathways

Oral submucous fibrosis (OSMF) is a chronic inflammatory disease and a potentially malignant oral disorder, characterized by fibrosis of the oral mucosa. TGF-β signaling pathways have been implicated in the development of OSMF, with areca nut extract (ANE) contributing to the disease progression. Si...

Full description

Saved in:
Bibliographic Details
Published in:Current Issues in Molecular Biology 2023-10, Vol.45 (11), p.8622-8632
Main Authors: Chang, Chi-Hua, Lin, Ching-Ping, Chen, Yuk-Kwan, Hsiao, Yu-Fang, Wang, Yan-Hsiung
Format: Article
Language:English
Subjects:
Antilipemic agents
areca nut extract
Collagen
collagen deposition
Fibrosis
Health aspects
oral submucous fibrosis
Simvastatin
Skin
TGF-β signaling pathway
Transforming growth factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!