Effect of Multicomponent Intervention on Functional Decline in Chinese Older Adults: A Multicenter Randomized Clinical Trial

Objectives To confirm whether multicomponent exercise following vivifrail recommendations was an effective method for improving physical ability, cognitive function, gait, balance, and muscle strength in Chinese older adults. Methods This was a multicenter and randomized clinical trial conducted in...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2023-11, Vol.27 (11), p.1063-1075
Main Authors: Chen, B., Li, M., Zhao, H., Liao, R., Lu, J., Tu, J., Zou, Y., Teng, X., Huang, Y., Liu, J., Huang, P., Wu, Jianqing
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Aged, 80 and over
Aging
Body composition
Clinical trials
East Asian People
Exercise
Frailty - prevention & control
Gait
Geriatrics/Gerontology
Health education
Humans
Medicine
Medicine & Public Health
Muscle Strength
Musculoskeletal system
Neurosciences
Nutrition
Older people
Original Research
Primary Care Medicine
Quality of Life Research
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Summary:Objectives To confirm whether multicomponent exercise following vivifrail recommendations was an effective method for improving physical ability, cognitive function, gait, balance, and muscle strength in Chinese older adults. Methods This was a multicenter and randomized clinical trial conducted in Jiangsu, China, from April 2021 to April 2022. Intervention lasted for 12 weeks and 104 older adults with functional declines were enrolled. All participants were randomly assigned to a control (usual care plus health education) or exercise group (usual care plus health education plus exercise). Primary outcomes were the change score of Short Physical Performance Battery (SPPB) and activities of daily living (ADL). The secondary outcomes included instrumental activities of daily living, Tinetti scores, Frailty score, short-form Mini Nutritional Assessment, Mini-Mental State Examination, Geriatric Depression Scale-15, the 12-item Short Form Survey, 4-meter gait speed test, 6-min walking distance, grip strength, and body composition analysis. Results Among the participants, the average age was 85 (82, 88) years. After 12 weeks of follow-up, the exercise group showed a significant improvement in SPPB, with a change of 2 points (95% confidence interval [0, 3.5], P
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-023-2031-9