Influence of circadian phase and extended wakefulness on glucose levels during forced desynchrony

Circadian misalignment and sleep deprivation often occur in tandem, and both negatively impact glucose homeostasis and metabolic health. The present study employed a forced desynchrony protocol to examine the influence of extended wakefulness and circadian misalignment on hourly glucose levels. Nine...

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Bibliographic Details
Published in:Sleep health 2024-02, Vol.10 (1), p.S96-S102
Main Authors: Broussard, Josiane L., Knud-Hansen, Brent C., Grady, Scott, Knauer, Oliver A., Ronda, Joseph M., Aeschbach, Daniel, Czeisler, Charles A., Wright, Kenneth P.
Format: Article
Language:English
Subjects:
Adult
Circadian misalignment
Circadian Rhythm - physiology
Forced desynchrony
Glucose metabolism
Homeostasis - physiology
Humans
Sleep - physiology
Sleep Deprivation
Wakefulness - physiology
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Summary:Circadian misalignment and sleep deprivation often occur in tandem, and both negatively impact glucose homeostasis and metabolic health. The present study employed a forced desynchrony protocol to examine the influence of extended wakefulness and circadian misalignment on hourly glucose levels. Nine healthy adults (4F/5M; 26 ± 4years) completed a 31-day in-laboratory protocol. After three 24 hour baseline days with 8 hours scheduled sleep opportunities, participants were scheduled to 14 consecutive 42.85 hour sleep-wake cycles, with 28.57 hours extended wakefulness and 14.28 hours sleep opportunities each cycle. Blood was sampled hourly across the forced desynchrony and over 600 plasma samples per participant were analyzed for glucose levels. Both hours into the 42.85 hours forced desynchrony day and circadian phase modulated glucose levels (p 
ISSN:2352-7218
2352-7226
DOI:10.1016/j.sleh.2023.10.010