Synthesis of Fluoren‐9‐ones via Pd‐Catalyzed Annulation of 2‐Iodobiphenyls with Vinylene Carbonate

A palladium‐catalyzed reaction for intermolecular selective C−H cyclocarbonylation of 2‐iodobiphenyls is described. Intriguingly, the vinylene carbonate acts as a carbon monoxide transfer agent to enable the annulation reaction. Moreover, as a versatile synthon, fluoren‐9‐one can be transformed into...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2024-02, Vol.19 (4), p.e202301040-n/a
Main Authors: Li, Wenguang, Yu, Yongqi, Yang, Jie, Fu, Kaifang, Zhang, Xu, Shi, Shukui, Li, Ting
Format: Article
Language:English
Subjects:
carbon monoxide transfer
Carboxylic acids
Chemical reactions
C−H activation
Organic chemistry
Palladium
palladium catalysis
versatile synthon
vinylene carbonate
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Summary:A palladium‐catalyzed reaction for intermolecular selective C−H cyclocarbonylation of 2‐iodobiphenyls is described. Intriguingly, the vinylene carbonate acts as a carbon monoxide transfer agent to enable the annulation reaction. Moreover, as a versatile synthon, fluoren‐9‐one can be transformed into a variety of functionalized organic molecules, such as [1,1′‐biphenyl]‐2‐carboxylic acid, 1′H,3′H‐spiro[fluorene‐9,2′‐perimidine] and N‐tosylhydrazones. A palladium‐catalyzed reaction for intermolecular selective C−H cyclocarbonylation of 2‐iodobiphenyls is reported, in which the vinylene carbonate acts as a carbon monoxide transfer agent to enable the annulation reaction.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202301040