Post-transplant monoclonal gammopathy of renal significance: a case report

•Monoclonal gammopathy represents a common hematologic disorder in the general population, including potential kidney transplant recipients•Monoclonal gammopathy on renal significance (MGRS) could worsen the survival of the allograft, especially in those untreated•There is no established treatment p...

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Bibliographic Details
Published in:Transplantation proceedings 2023-12, Vol.55 (10), p.2301-2303
Main Authors: Echeverri, Carolina Movilla, Cosano, Gema Montilla, Garrido, Carlos Rivera, Poblet, Marta Suñer, Benjumea, Alejandro Suarez
Format: Article
Language:English
Subjects:
Humans
immunosuppression
Kidney
Kidney Diseases - etiology
kidney transplantation
Kidney Transplantation - adverse effects
MGRS
Monoclonal Gammopathy of Undetermined Significance - complications
Monoclonal Gammopathy of Undetermined Significance - diagnosis
Monoclonal Gammopathy of Undetermined Significance - epidemiology
Paraproteinemias - complications
Paraproteinemias - diagnosis
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Summary:•Monoclonal gammopathy represents a common hematologic disorder in the general population, including potential kidney transplant recipients•Monoclonal gammopathy on renal significance (MGRS) could worsen the survival of the allograft, especially in those untreated•There is no established treatment protocol for PT-MGRS, so management is typically challenging with poor results. The term monoclonal gammopathy of renal significance (MGRS) has been used to classify the presence of a monoclonal gammopathy or lymphoproliferative disorders that do not meet hematological criteria for myeloma but instead, cause kidney damage. Mostly, post-transplant monoclonal gammopathy of renal significance (PT-MGRS) occurs due to recurrent disease. In contrast, the incidence of the novo PT-MGRS has not been established as it is considered a rare disease, presenting a unique challenge in terms of diagnosis, management, and potential impact on graft survival. Here, we report a case of de novo monoclonal gammopathy of renal significance diagnosed after kidney transplantation and its complexity due to a concomitant chronic active antibody-mediated rejection (cABMR).
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2023.09.005