Divergence and conservation of the meiotic recombination machinery

Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during meiosis. Meiotic recombination is almost universally conserved in its broad strokes, but specific molecular details often differ considerably between taxa, and the proteins that...

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Bibliographic Details
Published in:Nature reviews. Genetics 2024-05, Vol.25 (5), p.309-325
Main Authors: Arter, Meret, Keeney, Scott
Format: Article
Language:English
Subjects:
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631/337/149
Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chromosomes
Divergence
DNA Breaks, Double-Stranded
DNA damage
DNA Repair
Double-strand break repair
Evolutionary conservation
Gene Function
Homologous Recombination
Human Genetics
Meiosis
Meiosis - genetics
Molecular modelling
Phylogeny
Protein structure
Proteins
Recombinant DNA
Review Article
Yeast
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Summary:Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during meiosis. Meiotic recombination is almost universally conserved in its broad strokes, but specific molecular details often differ considerably between taxa, and the proteins that constitute the recombination machinery show substantial sequence variability. The extent of this variation is becoming increasingly clear because of recent increases in genomic resources and advances in protein structure prediction. We discuss the tension between functional conservation and rapid evolutionary change with a focus on the proteins that are required for the formation and repair of meiotic DNA double-strand breaks. We highlight phylogenetic relationships on different time scales and propose that this remarkable evolutionary plasticity is a fundamental property of meiotic recombination that shapes our understanding of molecular mechanisms in reproductive biology. In this Review, the authors describe the evolutionary conservation and divergence of the meiotic recombination machinery, focusing on proteins that are required for meiotic double-strand break formation, double-strand break repair via homologous recombination and the formation of crossover and non-crossover recombinant DNA molecules.
ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-023-00669-8