Exploration of rotational thromboelastometry (ROTEM) to characterize the coagulation profiles of newly diagnosed pediatric leukemia patients

Viscoelastic testing has been used in adult hematologic malignancies in conjunction with conventional coagulation tests (CCTs) to predict coagulopathies and tailor blood product replacement. However, there is a paucity of similar pediatric studies. Analyze and correlate leukemia-associated coagulopa...

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Bibliographic Details
Published in:Thrombosis research 2024-01, Vol.233, p.109-118
Main Authors: Malik, Marium, Al-Ghafry, Maha, Haimed, Abraham, Su, Julia, Lema, Maribel, Shore-Lessersson, Linda, Acharya, Suchitra S
Format: Article
Language:English
Subjects:
Adult
Blood Coagulation Disorders - diagnosis
Blood Coagulation Tests
Child
Fibrinogen - analysis
Humans
Leukemia - complications
Thrombelastography
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Summary:Viscoelastic testing has been used in adult hematologic malignancies in conjunction with conventional coagulation tests (CCTs) to predict coagulopathies and tailor blood product replacement. However, there is a paucity of similar pediatric studies. Analyze and correlate leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCT's and Rotational Thromboelastometry (ROTEM). Pediatric patients with newly diagnosed acute leukemia underwent testing with ROTEM and CCTs on days 0, 15 and 29 of induction chemotherapy. Sixty-two patients were enrolled. At presentation, 54.8 % of patients had platelets
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2023.11.019