Successful expansion of hospital-associated clone of vanA-positive vancomycin-resistant Enterococcus faecalis ST9 to an anthropogenically polluted mangrove in Brazil

Mangrove ecosystems are hotspots of biodiversity, but have been threatened by anthropogenic activities. Vancomycin-resistant enterococci (VRE) are nosocomial bacteria classified as high priority by the World Health Organization (WHO). Herein, we describe the identification and genomic characteristic...

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Bibliographic Details
Published in:Marine pollution bulletin 2024-01, Vol.198, p.115844-115844, Article 115844
Main Authors: Sacramento, Andrey G, Fuga, Bruna, Fontana, Herrison, Cardoso, Brenda, Esposito, Fernanda, Vivas, Roberto, Malta, Judson A O, Sellera, Fábio P, Lincopan, Nilton
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Brazil - epidemiology
Clone Cells
Cross Infection - microbiology
Ecosystem
Enterococcus faecalis - genetics
Enterococcus faecium
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - epidemiology
Gram-Positive Bacterial Infections - microbiology
Humans
Microbial Sensitivity Tests
Vancomycin
Vancomycin Resistance - genetics
Vancomycin-Resistant Enterococci - genetics
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Summary:Mangrove ecosystems are hotspots of biodiversity, but have been threatened by anthropogenic activities. Vancomycin-resistant enterococci (VRE) are nosocomial bacteria classified as high priority by the World Health Organization (WHO). Herein, we describe the identification and genomic characteristics of a vancomycin-resistant Enterococcus faecalis strain isolated from a highly impacted mangrove ecosystem of the northeastern Brazilian, in 2021. Genomic analysis confirmed the existence of the transposon Tn1546-vanA and clinically relevant antimicrobial resistance genes, such as streptogramins, tetracycline, phenicols, and fluoroquinolones. Virulome analysis identified several genes associated to adherence, immune modulation, biofilm, and exoenzymes production. The UFSEfl strain was assigned to sequence type (ST9), whereas phylogenomic analysis with publicly available genomes from a worldwide confirmed clonal relatedness with a hospital-associated Brazilian clone. Our findings highlight the successful expansion of hospital-associated VRE in a mangrove area and shed light on the need for strengthening genomic surveillance of WHO priority pathogens in these vital ecosystems.
ISSN:0025-326X
1879-3363
DOI:10.1016/j.marpolbul.2023.115844