Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes

The use of reactive gaseous reagents for the production of active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The implementation of continuous‐flow reactors has resulted in rapid development of gas‐handling technology because of several...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2024-03, Vol.63 (11), p.e202316108-n/a
Main Authors: Laporte, Annechien A. H., Masson, Tom M., Zondag, Stefan D. A., Noël, Timothy
Format: Article
Language:English
Subjects:
Atom economy
Chemical reactions
Chemical synthesis
Flow Chemistry
Gases
Handling
Heat transfer
Multiphase Reactions
Nuclear safety
Pharmaceuticals
Reactor
Reactors
Reagents
Synthetic Methodology
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Summary:The use of reactive gaseous reagents for the production of active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. The implementation of continuous‐flow reactors has resulted in rapid development of gas‐handling technology because of several advantages such as increased interfacial area, improved mass‐ and heat transfer, and seamless scale‐up. This technology enables shorter and more atom‐economic synthesis routes for the production of pharmaceutical compounds. Herein, we provide an overview of literature from 2016 onwards in the development of gas‐handling continuous‐flow technology as well as the use of gases in functionalization of APIs. Using highly reactive gases is appealing for efficient organic synthesis but leads to inherent safety and processing limitations. Embracing continuous‐flow technologies helps mitigating those while improving the performance of the systems. Tailored catalyst incorporation opens doors to novel reaction pathways and process intensification. Optimized mass transfer in multiphasic mixtures is key to its success, especially when solids are present.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202316108