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Compartmental Syndecan-1 (CD138) expression as a novel prognostic marker in triple-negative metaplastic breast cancer

Metaplastic breast cancer (MpBC) is rare, aggressive, and mostly triple-negative (TN) subtype of BC. We aimed to investigate the potential prognostic significance of Syndecan-1 (SDC1/CD138) expression in this unique tumor. Archived charts of 50 TNBC patients [21 MpBC and 29 invasive ductal carcinoma...

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Published in:Pathology, research and practice research and practice, 2024-01, Vol.253, p.154994-154994, Article 154994
Main Authors: Ismail, Yahia, Zakaria, Al-Shimaa, Allam, Rasha, Götte, Martin, Ibrahim, Sherif Abdelaziz, Hassan, Hebatallah
Format: Article
Language:English
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Summary:Metaplastic breast cancer (MpBC) is rare, aggressive, and mostly triple-negative (TN) subtype of BC. We aimed to investigate the potential prognostic significance of Syndecan-1 (SDC1/CD138) expression in this unique tumor. Archived charts of 50 TNBC patients [21 MpBC and 29 invasive ductal carcinoma (IDC)] were retrospectively evaluated. Corresponding paraffin blocks were used for immunohistochemical (IHC) staining of SDC1. Compartmental (epithelial membranous, stromal, and cytoplasmic) staining scores were expressed in quartiles (Q) and correlated with disease-free survival (DFS) and overall survival (OS). The median follow-up period was 54.6 months (range: 2.2–112.7). MpBC patients showed significantly worse DFS and OS than IDC (p = 0.007 and 0.004, respectively). MpBC demonstrated significantly higher Q4 stromal and membranous SDC1 compared to IDC (p = 0.016 and 0.021, respectively), whereas IDC exhibited significantly higher cytoplasmic Q4 SDC1 than MpBC (p = 0.015). Stromal Q4 SDC1 expression was found to be an independent factor associated with MpBC relative to IDC (OR: 6.7, 95% CI: 1.24–36.90; p = 0.028). Stromal Q4 SDC1 expression was also an independent prognostic parameter for worse DFS and OS compared to Q1–3 in the whole cohort (HR: 4.2, 95% CI: 1.6–10.5; p = 0.003 and HR: 5.8; 95% CI: 2.2–15.3; p 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154994