Invasive fungal sinusitis: A comparison of pediatric versus adult cases

Invasive fungal sinusitis (IFS) is a rare infection with high mortality, mainly impacting immunocompromised patients. Given its significant mortality, timely recognition and treatment is crucial. This study aims to highlight the differences in presentation of IFS between pediatric and adult patients...

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Published in:American journal of otolaryngology 2024-03, Vol.45 (2), p.104143-104143, Article 104143
Main Authors: Dacey, Sydney, Velu, Preetha S., Wilson, Nicholas, Levi, Jessica R., Paz-Lansberg, Marianella
Format: Article
Language:English
Subjects:
Adult
Child
Humans
Invasive Fungal Infections - diagnosis
Invasive Fungal Infections - drug therapy
Invasive Fungal Infections - epidemiology
Invasive fungal sinusitis
Nose
Paranasal Sinuses
Pediatrics
Rhinosinusitis
Sinusitis - drug therapy
Sinusitis - therapy
Systematic Reviews as Topic
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Summary:Invasive fungal sinusitis (IFS) is a rare infection with high mortality, mainly impacting immunocompromised patients. Given its significant mortality, timely recognition and treatment is crucial. This study aims to highlight the differences in presentation of IFS between pediatric and adult patients to aid in prompt diagnosis and treatment of this condition. A comprehensive literature search of PubMed, EMBASE, Web of Science, Global Index Medicus, Global Health (EBSCO) and Cochrane Database of Systematic Reviews was conducted to identify articles relating to IFS. Patient demographics, comorbidities, presentation, disease characteristics, treatments and outcomes were extracted from the studies, and statistical analyses were conducted to compare these variables between pediatric and adult patients. 111 studies identified 22 pediatric and 132 adult patients worldwide. Children were more likely to have hematologic malignancies compared to adults (59.1 % vs. 15.2 %, p 
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2023.104143