Whole genome identification of olive flounder (Paralichthys olivaceus) cathepsin genes: Provides insights into its regulation on biotic and abiotic stresses response

Cathepsins are major lysosomal enzymes involved in essential physiological processes, including protein degradation, tissue differentiation, and innate or adaptive responses. Several kinds of cathepsins have been reported in teleost fishes, but no characterization have been performed for the inflamm...

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Published in:Aquatic toxicology 2024-01, Vol.266, p.106783-106783, Article 106783
Main Authors: Xie, Qingping, Yao, Tingyan, Sun, Xuanyang, Liu, Xiumei, Wang, Xubo
Format: Article
Language:English
Subjects:
Animals
Cathepsins - genetics
Cathepsins - metabolism
Cloning, Molecular
Flounder - genetics
Flounder - metabolism
Phylogeny
Stress, Physiological - genetics
Water Pollutants, Chemical - toxicity
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Summary:Cathepsins are major lysosomal enzymes involved in essential physiological processes, including protein degradation, tissue differentiation, and innate or adaptive responses. Several kinds of cathepsins have been reported in teleost fishes, but no characterization have been performed for the inflammatory response of cathepsin family in olive flounder until now. In our current study, a total of 17 cathepsins in olive flounder were systematically identified and characterized. Phylogenetic analysis clearly indicated that the cathepsin genes was highly conserved. Analysis of structure and motifs exhibited high sequence similarity of cathepsin genes in olive flounder. Expression profiles of cathepsin genes in different tissues and developmental stages showed that cathepsins were temporally and spatially specific. RNA-seq analysis of bacteria and temperature stresses revealed that members of cathepsin were involved in inflammatory responses. Collectively, our findings would provide a further reference for understanding the molecular mechanisms of cathepsins in olive flounder.
ISSN:0166-445X
1879-1514
DOI:10.1016/j.aquatox.2023.106783