Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Background Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods A total of 2,084 cases and 7,102 controls from 11 studies in se...

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Published in:Cancer causes & control 2024-04, Vol.35 (4), p.727-737
Main Authors: Song, Minkyo, Jayasekara, Harindra, Pelucchi, Claudio, Rabkin, Charles S., Johnson, Kenneth C., Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Liao, Linda M., Bonzi, Rossella, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Castaño-Vinyals, Gemma, Guevara, Marcela, Tsugane, Shoichiro, Hamada, Gerson Shigueaki, Hidaka, Akihisa, Negri, Eva, Ward, Mary H., Sinha, Rashmi, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Curado, Maria Paula, Lunet, Nuno, Vioque, Jesus, Zhang, Zuo-Feng, La Vecchia, Carlo, Camargo, M. Constanza
Format: Article
Language:English
Subjects:
Biological activity
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Epidemiology
Female
Fertility
Gastric cancer
Gender differences
Health risks
Hematology
Hormones
Humans
Incidence
Life span
Male
Mens health
Oncology
Original Paper
Post-menopause
Premenopause
Public Health
Risk Factors
Stomach
Stomach Neoplasms - epidemiology
Stomach Neoplasms - etiology
Womens health
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Summary:Background Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis. Results A duration of fertility of ≥ 40 years (vs. 
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-023-01829-1