The predictive value of the neutrophil/platelet ratio on in-hospital adverse events and long-term prognosis in patients with coronary artery disease after percutaneous coronary intervention and its possible internal mechanism

The neutrophil-to-platelet ratio (NPR) is considered to be an indicator of inflammatory status. The value of the NPR in predicting in-hospital adverse events (AEs) and long-term prognosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients has not yet been report...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular biochemistry 2024-11, Vol.479 (11), p.3011-3019
Main Authors: Xiang, Yifei, Zeng, Jilang, Lin, Xueqin, Cai, Xiaoling, Zhang, Liwei, Luo, Manqing, Zhou, Gengyu, Chen, Xiaofang, Lin, Biting, Chen, Junhan, Chen, fan, Huang, Xuan, Guo, Yansong, Lin, Kai-Yang
Format: Article
Language:English
Subjects:
Adverse events
Aged
Angioplasty
Biochemistry
Biomedical and Life Sciences
Blood Platelets - metabolism
Blood Platelets - pathology
Cancer Research
Cardiology
Cardiovascular disease
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - mortality
Coronary vessels
Creatinine
Female
Heart
Heart diseases
Hospitals
Humans
Leukocytes (neutrophilic)
Life Sciences
Lipid metabolism
Lipids
Male
Medical Biochemistry
Middle Aged
Multivariate analysis
Neutrophils
Percutaneous Coronary Intervention - adverse effects
Platelets
Predictive Value of Tests
Prognosis
Regression analysis
Retrospective Studies
Risk Factors
Sensitivity analysis
Subgroups
Triglycerides
Vein & artery diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The neutrophil-to-platelet ratio (NPR) is considered to be an indicator of inflammatory status. The value of the NPR in predicting in-hospital adverse events (AEs) and long-term prognosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients has not yet been reported. Meanwhile, the mechanisms behind its predictive value for long-term prognosis remain unreported as well. The study retrospectively enrolled 7284 consecutive patients with CAD undergoing PCI from January 2012 to December 2018. Multivariable logistic regression analysis, multivariable Cox regression analysis, Kaplan‒Meier (KM) curve analysis, restricted cubic spline (RCS) curve analysis, and sensitivity analysis were used in the study. All-cause death was the endpoint of the study. According to the median value of the NPR, the patients were divided into two groups: the high group (NPR ≥ 0.02, n  = 3736) and the low group (NPR 
ISSN:0300-8177
1573-4919
1573-4919
DOI:10.1007/s11010-023-04901-1