Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Background Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and methods Computed tomography (CT)-scans performed preoperati...

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Bibliographic Details
Published in:International Journal of Obesity 2024-04, Vol.48 (4), p.533-541
Main Authors: Kays Mohammed Ali, Younes, Dolin, Troels Gammeltoft, Damm Nybing, Janus, Lykke, Jakob, Hvid Linden, Frederik, Høgh-Schmidt, Erik, Sørensen, Thorkild I. A., Christensen, Jesper Frank, Nielsen, Yousef J. W., Stenfatt Larsen, Jim, Madsbad, Sten, Sidenius Johansen, Julia, Svane, Maria Saur, Lang Lehrskov, Louise
Format: Article
Language:English
Subjects:
692/163
692/163/2743/2037
692/163/2743/393
Abdomen
Adipose tissue
Bioaccumulation
Body fat
Cancer surgery
Colon
Colon cancer
Colorectal cancer
Computed tomography
Epidemiology
Health Promotion and Disease Prevention
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Obesity
Public Health
Surgery
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Summary:Background Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and methods Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately. Results A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2–9%, p  
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-023-01445-8