Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns

• Published in: Journal of perinatology 2024-04, Vol.44 (4), p.554-560
• Main Authors: Valentine, Gregory C., Perez, Krystle M., Wood, Thomas R., Mayock, Dennis E., Law, Janessa B., Kolnik, Sarah, Strobel, Katie M., Brandon, Olivia C., Comstock, Bryan A., Heagerty, Patrick J., Juul, Sandra E.
• Format: Article
• Language: English
• Subjects: 631/443/319; 692/499; 692/700/1720; Birth Weight; Child; Child development; Cognitive ability; Developmental Disabilities - epidemiology; Developmental Disabilities - etiology; Erythropoietin; Humans; Infant; Infant, Extremely Premature; Infant, Newborn; Medicine; Medicine & Public Health; Neonates; Neurodevelopment; Neurodevelopmental disorders; Neuroprotection; Pediatric Surgery; Pediatrics; Premature babies; Premature birth; Registration; Secondary analysis; Weight Loss
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/s41372-024-01869-8

Objective Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns. Study design Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition. Results Among n  = 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: −5.0 points, [CI −9.5, −0.6]) and lower motor scores (≤1 day versus ≥8 days: −4.6 points [CI −9.2, −0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤−50 percent-days: −5.6, [CI −9.4, −1.8]), motor scores (≤−50 percent-days: −4.2, [CI -8.2, -0.2]); and language scores (≤−50 percent-days: −6.0, [CI −10.1, −1.9]). Conclusion Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes. Trial registration PENUT Trial Registration: NCT01378273. https://clinicaltrials.gov/ct2/show/NCT01378273 . Clinical trial registration This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).