Associations of relative fat mass and BMI with all-cause mortality: Confounding effect of muscle mass

• Published in: Obesity (Silver Spring, Md.) Md.), 2024-03, Vol.32 (3), p.603-611
• Main Authors: Suthahar, Navin, Zwartkruis, Victor, Geelhoed, Bastiaan, Withaar, Coenraad, Meems, Laura M G, Bakker, Stephan J L, Gansevoort, Ron T, van Veldhuisen, Dirk Jan, Rienstra, Michiel, de Boer, Rudolf A
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Body Mass Index; Cancer; Cardiovascular disease; Creatinine; Diabetes; Female; Glucose; Humans; Hypertension; Kidney diseases; Male; Middle Aged; Mortality; Muscles; Obesity; Overweight; Proportional Hazards Models; Regression analysis; Smoking cessation; Urine; Womens health
• ISSN: 1930-7381; 1930-739X; 1930-739X
• DOI: 10.1002/oby.23953

The study objective was to examine associations of relative fat mass (RFM) and BMI with all-cause mortality in the Dutch general population and to investigate whether additional adjustment for muscle mass strengthened these associations. A total of 8433 community-dwelling adults from the PREVEND general population cohort (1997-1998) were included. Linear regression models were used to examine associations of RFM and BMI with 24-h urinary creatinine excretion, a marker of total muscle mass. Cox regression models were used to examine associations of RFM and BMI with all-cause mortality. The mean age of the cohort was 49.8 years (range: 28.8-75.7 years), and 49.9% (n = 4209) were women. In age- and sex-adjusted models, both RFM and BMI were associated with total muscle mass (24-h urinary creatinine excretion), and these associations were stronger with BMI (standardized beta [Sβ] : 0.29; 95% CI: 0.27-0.31 vs. Sβ : 0.38; 95% CI: 0.36-0.40; p