Structural determinants for tRNA selective cleavage by RNase 2/EDN

tRNA-derived fragments (tRFs) have emerged as key players of immunoregulation. Some RNase A superfamily members participate in the shaping of the tRFs population. By comparing wild-type and knockout macrophage cell lines, our previous work revealed that RNase 2 can selectively cleave tRNAs. Here, we...

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Bibliographic Details
Published in:Structure (London) 2024-03, Vol.32 (3), p.328-341.e4
Main Authors: Li, Jiarui, Kang, Xincheng, Guidi, Irene, Lu, Lu, Fernández-Millán, Pablo, Prats-Ejarque, Guillem, Boix, Ester
Format: Article
Language:English
Subjects:
Anticodon
Cleavage site
Endoribonucleases - genetics
Protein-RNA binding
RNA
RNA, Transfer - chemistry
RNases
Substrate selectivity
tRFs
tRNA
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