Association between High HbA1c Levels and Mast Cell Phenotype in the Infrapatellar Fat Pad of Patients with Knee Osteoarthritis

Diabetes mellitus (DM) has been suggested as a potential risk factor for knee osteoarthritis (KOA), and its underlying mechanisms remain unclear. The infrapatellar fat pad (IPFP) contributes to OA through inflammatory mediator secretion. Mast cells' (MCs) role in diabetic IPFP pathology is uncl...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-01, Vol.25 (2), p.877
Main Authors: Tsukada, Ayumi, Takata, Ken, Aikawa, Jun, Iwase, Dai, Mukai, Manabu, Uekusa, Yui, Metoki, Yukie, Inoue, Gen, Miyagi, Masayuki, Takaso, Masashi, Uchida, Kentaro
Format: Article
Language:English
Subjects:
Arthritis
Body fat
Body mass index
Diabetes
Diabetes Mellitus - genetics
Gene expression
Genetic aspects
Glycated Hemoglobin
Glycosylated hemoglobin
Health aspects
Humans
Knee
Mast Cells
Metabolism
Obesity
Osteoarthritis
Osteoarthritis, Knee - genetics
Overweight
Pathophysiology
Patients
Phenotype
Risk factors
Serine Proteases
Skin
Tumor necrosis factor-TNF
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Summary:Diabetes mellitus (DM) has been suggested as a potential risk factor for knee osteoarthritis (KOA), and its underlying mechanisms remain unclear. The infrapatellar fat pad (IPFP) contributes to OA through inflammatory mediator secretion. Mast cells' (MCs) role in diabetic IPFP pathology is unclear. In 156 KOA patients, hemoglobin A1c (HbA1c) was stratified (HbA1c ≥ 6.5, = 28; HbA1c < 6.5, = 128). MC markers ( , ) in IPFP were studied. Propensity-matched cohorts ( = 27 each) addressed demographic differences. MC-rich fraction (MC-RF) and MC-poor fraction (MC-PF) were isolated, comparing MC markers and genes elevated in diabetic skin-derived MC ( , , , ). and expression were significantly higher in HbA1c ≥ 6.5 vs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25020877