Low‐dose sugammadex reverses moderate rocuronium‐induced neuromuscular block in horses

Background Neuromuscular block (NMB) during general anaesthesia has an implicit risk of inadvertent residual NMB during recovery. Reversal of NMB is commonly encouraged to decrease this risk, and has historically been performed with neostigmine/atropine, two agents with important cardiac and gastroi...

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Bibliographic Details
Published in:Equine veterinary journal 2025-01, Vol.57 (1), p.265-270
Main Authors: Martin‐Flores, Manuel, Sakai, Daniel M., Araos, Joaquin, Campoy, Luis
Format: Article
Language:English
Subjects:
acceleromyography
anaesthesia
Anesthesia Recovery Period
Animals
Dose-Response Relationship, Drug
Female
horse
Horses
Male
Neuromuscular Blockade - veterinary
Neuromuscular Nondepolarizing Agents - administration & dosage
Neuromuscular Nondepolarizing Agents - pharmacology
relaxant
Rocuronium - administration & dosage
Rocuronium - pharmacology
Sugammadex - administration & dosage
Sugammadex - pharmacology
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Summary:Background Neuromuscular block (NMB) during general anaesthesia has an implicit risk of inadvertent residual NMB during recovery. Reversal of NMB is commonly encouraged to decrease this risk, and has historically been performed with neostigmine/atropine, two agents with important cardiac and gastrointestinal side effects. Sugammadex is a new selective relaxant binding agent that can reverse rocuronium‐induced NMB efficiently and without these complications. Recommended doses are possibly cost‐prohibitive. Objectives To measure the recovery time from rocuronium‐NMB after administration of low‐dose sugammadex, compared with spontaneous recovery. Study design Nonrandomised in vivo experiments. Methods Fourteen adult horses undergoing different research procedures were anaesthetised with detomidine and isoflurane. All horses received NMB with rocuronium 0.3 mg/kg IV. Neuromuscular function was measured with acceleromyographic train‐of‐four (TOF) ratio. Recovery occurred spontaneously in five horses weighing (median [range]) 548 (413–594) kg and was enhanced with sugammadex 200 mg (total dose) in nine horses (433 [362–515]) kg. Recovery time from moderate NMB to a TOF ratio 1.0, and total duration of NMB were compared between groups. Cases of recurarisation (decrease in the TOF ratio
ISSN:0425-1644
2042-3306
2042-3306
DOI:10.1111/evj.14066