Multifold Post‐Modification of Macrocycles and Cages by Isocyanate‐Induced Azadefluorination Cyclisation

• Published in: Angewandte Chemie International Edition 2024-04, Vol.63 (15), p.e202318362-n/a
• Main Authors: Pausch, Tobias, David, Tim, Fleck‐Kunde, Tom, Pols, Hendrik, Gurke, Johannes, Schmidt, Bernd M.
• Format: Article
• Language: English
• Subjects: Cages; Chemical compounds; Chemical reactions; Cross coupling; dynamic covalent chemistry; Fluorine; Functional groups; Isocyanates; macrocycles; Mathematical analysis; NMR; Nuclear magnetic resonance; Self-assembly; supramolecular cages; supramolecular chemistry
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202318362

We present the multiple post‐modification of organic macrocycles and cages, introducing functional groups into two‐ and three‐dimensional supramolecular scaffolds bearing fluorine substituents, which opens up new possibilities in multi‐step supramolecular chemistry employing the vast chemical space of readily available isocyanates. The mechanism and scope of the reaction that proceeds after isocyanate addition to the benzylamine motif via an azadefluorination cyclisation (ADFC) were investigated using DFT calculations, and a series of aromatic isocyanates with different electronic properties were tested. The compounds show excellent chemical stability and were fully characterised. They can be used for subsequent cross‐coupling reactions, and ADFC can be used directly to generate cross‐linked membranes from macrocycles or cages when using ditopic isocyanates. Single‐crystal X‐ray (SC‐XRD) analysis shows the proof of the formation of the desired supramolecular entity together with the connectivity predicted by calculations and from 19F NMR shifts, allowing the late‐stage functionalisation of self‐assembled macrocycles and cages by ADFC. We introduce functional groups into two‐ and three‐dimensional supramolecular scaffolds bearing fluorine substituents through azadefluorination cyclisation (ADFC), which enables multistep supramolecular chemistry using readily available isocyanates, allowing the functionalization of self‐assembled macrocycles and cages′ exterior chemical spaces. With ditopic isocyanates, ADFC can be used to create cross‐linked membranes from supramolecular entities.