Effect of sodium alginate block type on the physicochemical properties and curcumin release behavior of quaternized chitosan-oxidized sodium alginate Schiff base hydrogels

• Published in: Food chemistry 2024-06, Vol.444, p.138688-138688, Article 138688
• Main Authors: Wang, Qi, Yan, Shizhang, Ning, Yijie, Zhu, Yan, Sergeeva, Irina, Li, Yang, Qi, Baokun
• Format: Article
• Language: English
• Subjects: Aldehydes; Alginates - chemistry; Chitosan - chemistry; Controlled-release; Curcumin; Hydrogels - chemistry; Injectable self-healing hydrogel; M/G ratio; Oxidized sodium alginate; Quaternized chitosan; Schiff base; Schiff Bases - chemistry
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2024.138688

QCS-OSA hydrogels synergistically crosslinked via Schiff base bonding and electrostatic interactions for controlled curcumin release. [Display omitted] •The aldehyde content of OSA was adjusted by controlling the M/G ratio.•Hydrogels based on Schiff base and electrostatic synergic cross-linking.•Hydrogels were injectable and self-healing with excellent rheological behavior.•Controlled curcumin release by modulating the network structure of hydrogels. Controlling bioactive ingredients release by modulating the 3D network structure of cross-linked hydrogels is important for functional food development. Hereby, oxidized sodium alginate (OSA) with varying aldehyde contents was formed by periodate oxidation of sodium alginate (SA) with different β-d-mannuronic acid (M) and α-l-guluronic acid (G) ratios (M/G = 1:2, 1:1, and 2:1) and its structure was characterized. Moreover, hydrogels were prepared via Schiff base and electrostatic interactions between quaternized chitosan (QCS) and OSA. The properties of hydrogels such as microstructure, thermal stability, swelling and controlled release were investigated. The results showed that OSA with M/G = 1:2 had the highest content of aldehyde groups, and the hydrogel formed by it and QCS had higher thermal stability and a denser network structure with the lowest equilibrium swelling rate, which could better control the release of curcumin. Additionally, it had good self-healing and can recover rapidly after the rupture of its network structure.