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Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study
Objective: This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization. Methods: Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different t...
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| Published in: | Endocrine 2024-07, Vol.85 (1), p.158-167 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | 167 |
| container_issue | 1 |
| container_start_page | 158 |
| container_title | Endocrine |
| container_volume | 85 |
| creator | Qiu, Zhengqi Jia, Xueyuan Li, Yufei Fu, Yancheng Xiao, Ying |
| description | Objective:
This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
Methods:
Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM.
Results:
The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00,
P
|
| doi_str_mv | 10.1007/s12020-024-03723-5 |
| format | article |
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This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
Methods:
Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM.
Results:
The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00,
P
< 0.01). However, no significant causal relationship was observed between computer usage time and the risk of T2DM. Additionally, mobile phone use time showed a positive correlation with the risk of T2DM (OR: 1.31, 95% CI: 1.04 to 1.64,
P
= 0.02), albeit to a lesser extent than television viewing time.
Conclusion:
The findings of this study indicate a significant causal association between certain types of screen time, specifically television viewing and mobile phone use, and an increased risk of T2DM.</description><identifier>ISSN: 1559-0100</identifier><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-024-03723-5</identifier><identifier>PMID: 38347339</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cell Phone ; Cellular telephones ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - genetics ; Endocrinology ; Genetic diversity ; Genetic Predisposition to Disease ; Humanities and Social Sciences ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mendelian Randomization Analysis ; multidisciplinary ; Original Article ; Polymorphism, Single Nucleotide ; Risk Factors ; Science ; Screen Time ; Single-nucleotide polymorphism ; Television - statistics & numerical data</subject><ispartof>Endocrine, 2024-07, Vol.85 (1), p.158-167</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-b6de4bdda38a9d8d510d2919092bcab59ac0ef274a44696e78b43d356daae9083</cites><orcidid>0000-0001-5178-1706</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38347339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Zhengqi</creatorcontrib><creatorcontrib>Jia, Xueyuan</creatorcontrib><creatorcontrib>Li, Yufei</creatorcontrib><creatorcontrib>Fu, Yancheng</creatorcontrib><creatorcontrib>Xiao, Ying</creatorcontrib><title>Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Objective:
This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
Methods:
Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM.
Results:
The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00,
P
< 0.01). However, no significant causal relationship was observed between computer usage time and the risk of T2DM. Additionally, mobile phone use time showed a positive correlation with the risk of T2DM (OR: 1.31, 95% CI: 1.04 to 1.64,
P
= 0.02), albeit to a lesser extent than television viewing time.
Conclusion:
The findings of this study indicate a significant causal association between certain types of screen time, specifically television viewing and mobile phone use, and an increased risk of T2DM.</description><subject>Cell Phone</subject><subject>Cellular telephones</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endocrinology</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mendelian Randomization Analysis</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Screen Time</subject><subject>Single-nucleotide polymorphism</subject><subject>Television - statistics & numerical data</subject><issn>1559-0100</issn><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUlPHDEQha2IiGXCH8ghssRlODQp2705N8QWpEEcmJwtd7sGjLrtju0GDb-eHoYsyiGnKqm-evVUj5DPDE4YQPU1Mg4cMuB5BqLiIis-kH1WFDKDab7zV79HDmJ8BOCcl9Uu2RO1yCsh5D5xd21AdDTZHqmd6gNSg0_Y-aFHl6hf0bQekHJqrG4wYaQ9dp1NY6TzJT-_OabfqKbp2WdR90OH9Aadwc5qR4N2xvf2RSfrHY1pNOtP5ONKdxEP3-uM_Li8WJ59zxa3V9dnp4usFbxMWVMazBtjtKi1NLUpGBgumQTJm1Y3hdQt4IpXuc7zUpZY1U0ujChKozVKqMWMzLe6Q_A_R4xJ9Ta2k3Ht0I9RcclLqOrNE2bk6B_00Y_BTe6UgErKguWsmCi-pdrgYwy4UkOwvQ5rxUBt0lDbNNSUhnpLQ22WvrxLj02P5vfKr_dPgNgCcRq5ewx_bv9H9hUr2pRK</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Qiu, Zhengqi</creator><creator>Jia, Xueyuan</creator><creator>Li, Yufei</creator><creator>Fu, Yancheng</creator><creator>Xiao, Ying</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5178-1706</orcidid></search><sort><creationdate>20240701</creationdate><title>Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study</title><author>Qiu, Zhengqi ; Jia, Xueyuan ; Li, Yufei ; Fu, Yancheng ; Xiao, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b6de4bdda38a9d8d510d2919092bcab59ac0ef274a44696e78b43d356daae9083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cell Phone</topic><topic>Cellular telephones</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endocrinology</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mendelian Randomization Analysis</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Screen Time</topic><topic>Single-nucleotide polymorphism</topic><topic>Television - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Zhengqi</creatorcontrib><creatorcontrib>Jia, Xueyuan</creatorcontrib><creatorcontrib>Li, Yufei</creatorcontrib><creatorcontrib>Fu, Yancheng</creatorcontrib><creatorcontrib>Xiao, Ying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Zhengqi</au><au>Jia, Xueyuan</au><au>Li, Yufei</au><au>Fu, Yancheng</au><au>Xiao, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>85</volume><issue>1</issue><spage>158</spage><epage>167</epage><pages>158-167</pages><issn>1559-0100</issn><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Objective:
This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization.
Methods:
Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM.
Results:
The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00,
P
< 0.01). However, no significant causal relationship was observed between computer usage time and the risk of T2DM. Additionally, mobile phone use time showed a positive correlation with the risk of T2DM (OR: 1.31, 95% CI: 1.04 to 1.64,
P
= 0.02), albeit to a lesser extent than television viewing time.
Conclusion:
The findings of this study indicate a significant causal association between certain types of screen time, specifically television viewing and mobile phone use, and an increased risk of T2DM.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38347339</pmid><doi>10.1007/s12020-024-03723-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5178-1706</orcidid></addata></record> |
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| subjects | Cell Phone Cellular telephones Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Endocrinology Genetic diversity Genetic Predisposition to Disease Humanities and Social Sciences Humans Internal Medicine Medicine Medicine & Public Health Mendelian Randomization Analysis multidisciplinary Original Article Polymorphism, Single Nucleotide Risk Factors Science Screen Time Single-nucleotide polymorphism Television - statistics & numerical data |
| title | Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study |
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