Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study

• Published in: Nutritional neuroscience 2024-11, Vol.27 (11), p.1220-1225
• Main Authors: Deng, Xinmin, Zhu, Jingyi, Liang, Jingtao, Chang, Wen, Lv, Xiaofeng, Lai, Rui
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - epidemiology; Alzheimer Disease - genetics; Diet; Edible Grain; Fruit; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Vegetables
• ISSN: 1028-415X; 1476-8305; 1476-8305
• DOI: 10.1080/1028415X.2024.2312685

Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization. We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls. Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82-0.95). No causal association was found between the intake of other foods and AD. This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.