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Solvent polarity and hydrophobicity of solutes are two sides of the same coin

The hydrophobicity of solutes measures the intensity of a solute's interaction with aqueous environment. The aqueous environment may change with its composition, leading to changes in its solvent properties largely characterized by polarity. As a result, the relative hydrophobicity of a solute...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2024-03, Vol.701, p.149600, Article 149600
Main Authors: Madeira, Pedro P., Todorov, German, Uversky, Vladimir N., Zaslavsky, Boris Y.
Format: Article
Language:English
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Summary:The hydrophobicity of solutes measures the intensity of a solute's interaction with aqueous environment. The aqueous environment may change with its composition, leading to changes in its solvent properties largely characterized by polarity. As a result, the relative hydrophobicity of a solute is a function of the solute structure and the properties of the water-based solvent determined by the total composition of the aqueous phase. This aspect is commonly ignored by medicinal chemists even though it is essential for drug distribution between different biological tissues. Partitioning of solutes in aqueous two-phase systems provides the relative hydrophobicity estimates for any water-soluble compounds that can be used to improve predictions of the toxicity and other biological effects of these compounds. •Hydrophobicity of solutes measures the intensity of a solute's interaction with aqueous environment.•The aqueous environment changes with its composition, leading to changes in polarity.•The relative hydrophobicity of a solute is a function of the polarity.•Partitioning of solutes in aqueous two-phase systems provides the relative hydrophobicity estimates.
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2024.149600