Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma

Background Cutaneous melanoma is characterized by a high risk of metastasis to distant organs and a substantial mortality rate. For planning treatment and assessing outcomes, the Breslow micrometric measurement is critical. The tumor macroscopic dimension is not considered a prognostic parameter in...

Full description

Saved in:
Bibliographic Details
Published in:International journal of dermatology 2024-06, Vol.63 (6), p.765-772
Main Authors: Asato, Marcel A., Moraes‐Neto, Francisco A., Moraes, Marcelo Padovani de Toledo, Ocanha‐Xavier, Juliana P., Alencar Marques, Mariangela Esther, Xavier‐Junior, Jose Candido C.
Format: Article
Language:English
Subjects:
Biopsy
Evaluation
Lymph nodes
Lymphatic system
Medical prognosis
Melanoma
Metastases
Mitosis
Multivariate analysis
Parameters
Statistical analysis
Survival
Survival analysis
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Cutaneous melanoma is characterized by a high risk of metastasis to distant organs and a substantial mortality rate. For planning treatment and assessing outcomes, the Breslow micrometric measurement is critical. The tumor macroscopic dimension is not considered a prognostic parameter in cutaneous melanoma, although there are studies showing that tumor size is an independent prognostic factor for melanoma‐specific survival. Therefore, this study aimed to evaluate the macroscopic dimension of melanoma and other known prognostic factors (i.e., Breslow index, mitoses, regression, and ulceration) as predictors of sentinel lymph node outcome and survival outcome. Methods We performed a retrospective cross‐sectional study of 227 melanoma lesions subjected to sentinel lymph node biopsy at two Brazilian referral centers. Results On univariate analysis, there was a statistically significant correlation between the largest macroscopic tumor dimension and the sentinel lymph node result (P = 0.001); however, on multivariate analysis considering all evaluated parameters, there was no significant difference between the sentinel lymph node result and the tumor macroscopic dimension (P = 0.2689). Regarding melanoma‐specific survival, the macroscopic dimension showed no significant correlation (P = 0.4632) in contrast to Breslow's dimension (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.17024