Acute Kidney Injury Following Transcatheter Aortic Valve Implantation—A Contemporary Perspective of Incidence, Predictors, and Outcomes

Acute kidney injury (AKI) is a known complication following transcatheter aortic valve implantation (TAVI), associated with increased morbidity and mortality. Most of this data relates to higher-risk patients with early-generation TAVI valves. With TAVI now established as a safe and cost-effective p...

Full description

Saved in:
Bibliographic Details
Published in:Heart, lung & circulation lung & circulation, 2024-03, Vol.33 (3), p.316-323
Main Authors: Butala, Anant D., Nanayakkara, Shane, Navani, Rohan V., Palmer, Sonny, Noaman, Samer, Haji, Kawa, Htun, Nay M., Walton, Antony S., Stub, Dion
Format: Article
Language:English
Subjects:
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Aged, 80 and over
Aortic stenosis
Aortic Valve - surgery
Aortic Valve Stenosis - surgery
Comorbidity
Contrast induced nephropathy
Female
Humans
Incidence
Kidney injury
Male
Risk Factors
TAVI
Transcatheter Aortic Valve Replacement - adverse effects
Transcatheter Aortic Valve Replacement - methods
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute kidney injury (AKI) is a known complication following transcatheter aortic valve implantation (TAVI), associated with increased morbidity and mortality. Most of this data relates to higher-risk patients with early-generation TAVI valves. With TAVI now established as a safe and cost-effective procedure for low-risk patients, there is a distinct need for updated analysis. We aimed to assess the incidence, predictors, and outcomes of AKI in a contemporary cohort of TAVI patients, concurrently examining the role of temporal evolution on AKI. A total of 2,564 patients undergoing TAVI from 2008–2023 included in the Alfred-Cabrini-Epworth (ACE) TAVI Registry were analysed. Patients were divided into AKI and no AKI groups. Outcomes were reported according to the Valve Academic Research Consortium-3 (VARC-3) criteria. Of 2,564 patients, median age 83 (78–87) years, 57.4% men and a median Society of Thoracic Surgeons score of 3.6 (2.4–5.5), 163 (6.4%) patients developed AKI with incidence falling from 9.7% between 2008–2014 to 6% between 2015–2023 (p=0.022). On multivariable analysis, independent predictors of AKI were male sex (adjusted odds ratio [aOR] 1.89, p=0.005), congestive cardiac failure (aOR 1.52, p=0.048), estimated glomerular filtration rate 30–59 (aOR: 2.79, p
ISSN:1443-9506
1444-2892
DOI:10.1016/j.hlc.2023.11.018