Diffusional kurtosis imaging in differentiating nonarteritic anterior ischemic optic neuropathy from acute optic neuritis

Purpose We aimed to determine the feasibility of using DKI to characterize pathological changes in nonarteritic anterior ischemic optic neuropathy (NAION) and to differentiate it from acute optic neuritis (ON). Methods Orbital DKI was performed with a 3.0 T scanner on 75 patients (51 with NAION and...

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Bibliographic Details
Published in:Neuroradiology 2024-05, Vol.66 (5), p.797-807
Main Authors: Lu, Ping, Hong, Rujian, Tian, Guohong, Liu, Xilan, Sha, Yan, Zhang, Jibin, Wang, Ximing
Format: Article
Language:English
Subjects:
Abnormalities
Advanced Neuroimaging
Anisotropy
Correlation analysis
Correlation coefficient
Correlation coefficients
Diagnosis
Differential diagnosis
Diffusion Magnetic Resonance Imaging - methods
Diffusion Tensor Imaging - methods
Diffusivity
Humans
Imaging
Ischemia
Kurtosis
Mathematical analysis
Medicine
Medicine & Public Health
Nerves
Neuritis
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Optic neuritis
Optic Neuritis - diagnostic imaging
Optic neuropathy
Optic Neuropathy, Ischemic - diagnostic imaging
Parameters
Radiology
ROC Curve
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Summary:Purpose We aimed to determine the feasibility of using DKI to characterize pathological changes in nonarteritic anterior ischemic optic neuropathy (NAION) and to differentiate it from acute optic neuritis (ON). Methods Orbital DKI was performed with a 3.0 T scanner on 75 patients (51 with NAION and 24 with acute ON) and 15 healthy controls. NAION patients were further divided into early and late groups. The mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) were calculated to perform quantitative analyses among groups; and receiver operating characteristic curve analyses were also performed to determine their effectiveness of differential diagnosis. In addition, correlation coefficients were calculated to explore the correlations of the DKI-derived data with duration of disease. Results The MK, RK, and AK in the affected nerves with NAION were significantly higher than those in the controls, while the trend of FA, RD, and AD was a decline; in acute ON patients, except for RD, which increased, all DKI-derived kurtosis and diffusion parameters were significantly lower than controls (all P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-024-03301-6