Relationships between cortisol levels across early childhood and processing speed at age 4.5 years in children born very preterm

Children born very low gestational age (VLGA, 29-32 weeks gestational age [GA]) display slower processing speed and altered hypothalamic pituitary adrenal (HPA) axis function, with greater effects in those born extremely low gestational age (ELGA; 24-28 weeks GA). We investigated trajectories of HPA...

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Bibliographic Details
Published in:Child neuropsychology 2024-11, Vol.30 (8), p.1215-1233
Main Authors: McLean, Mia A., Weinberg, Joanne, Synnes, Anne R., Miller, Steven P., Grunau, Ruth E.
Format: Article
Language:English
Subjects:
Child Development - physiology
Child, Preschool
cognition
cortisol
Female
Humans
Hydrocortisone - analysis
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - metabolism
Infant
Infant, Extremely Premature - physiology
Infant, Newborn
Longitudinal Studies
Male
Pituitary-Adrenal System - metabolism
preterm
Processing Speed
Prospective Studies
Saliva - chemistry
Saliva - metabolism
Stress
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Summary:Children born very low gestational age (VLGA, 29-32 weeks gestational age [GA]) display slower processing speed and altered hypothalamic pituitary adrenal (HPA) axis function, with greater effects in those born extremely low gestational age (ELGA; 24-28 weeks GA). We investigated trajectories of HPA axis activity as indexed by cortisol output and patterns across cognitive assessment at ages 1.5, 3 and 4.5 years, comparing children born ELGA and VLGA and associations with 4.5-year processing speed. In a prospective longitudinal cohort study, infants born very preterm (
ISSN:0929-7049
1744-4136
1744-4136
DOI:10.1080/09297049.2024.2314958