Transrectal ultrasound for intraoperative interstitial needle guidance in cervical cancer brachytherapy

• Published in: Strahlentherapie und Onkologie 2024-08, Vol.200 (8), p.684-690
• Main Authors: Knoth, J., Sturdza, A., Zaharie, A., Dick, V., Kronreif, G., Nesvacil, N., Widder, J., Kirisits, C., Schmid, M. P
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brachytherapy - instrumentation; Brachytherapy - methods; Cancer; Cervical cancer; Female; Humans; Image quality; Insertion; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Needles; Neoplasm Staging; Oncology; Original Article; Prospective Studies; Radiation therapy; Radiotherapy; Radiotherapy, Image-Guided - instrumentation; Radiotherapy, Image-Guided - methods; Rectum - diagnostic imaging; Rectum - radiation effects; Risk; Transplants & implants; Ultrasonic imaging; Ultrasonic testing; Ultrasonography, Interventional - methods; Uterine Cervical Neoplasms - diagnostic imaging; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Visibility
• ISSN: 0179-7158; 1439-099X; 1439-099X
• DOI: 10.1007/s00066-024-02207-9

Objective This study aimed to prospectively assess the visibility of interstitial needles on transrectal ultrasound (TRUS) in cervical cancer brachytherapy patients and evaluate its impact on implant and treatment plan quality. Material and methods TRUS was utilized during and after applicator insertion, with each needle’s visibility documented through axial images at the high-risk clinical target volume’s largest diameter. Needle visibility on TRUS was scored from 0 (no visibility) to 3 (excellent discrimination, margins distinct). Quantitative assessment involved measuring the distance between tandem and each needle on TRUS and comparing it to respective magnetic resonance imaging (MRI) measurements. Expected treatment plan quality based on TRUS images was rated from 1 (meeting all planning objectives) to 4 (violation of High-risk clinical target volume (CTV HR ) and/or organ at risk (OAR) hard constraints) and compared to the final MRI-based plan. Results Analysis included 23 patients with local FIGO stage IB2-IVA, comprising 41 applications with a total of 230 needles. A high visibility rate of 99.1% (228/230 needles) was observed, with a mean visibility score of 2.5 ± 0.7 for visible needles. The maximum and mean difference between MRI and TRUS measurements were 8 mm and –0.1 ± 1.6 mm, respectively, with > 3 mm discrepancies in 3.5% of needles. Expected treatment plan quality after TRUS assessment exactly aligned with the final MRI plan in 28 out of 41 applications with only minor deviations in all other cases. Conclusion Real-time TRUS-guided interstitial needle placement yielded high-quality implants, thanks to excellent needle visibility during insertion. This supports the potential of TRUS-guided brachytherapy as a promising modality for gynecological indications.