Newborn phosphocalcic metabolism after intravenous iron administration during pregnancy

Iron deficiency anemia is a very common health problem during pregnancy and intravenous (IV) iron substitution has become part of routine management. However, recent studies have raised concerns about the association of IV iron infusion and the development of secondary transitory hypophosphatemia (H...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2024-12, Vol.37 (1), p.2320671-2320671
Main Authors: Schumacher, Fanny, Barcos-Munoz, Francisca, Kunckler, Margot, Vuilleumier, Nicolas, Martinez de Tejada, Begoña
Format: Article
Language:English
Subjects:
Administration, Intravenous
Adult
Anemia, Iron-Deficiency - drug therapy
Calcium
Female
Ferric Compounds - adverse effects
Hemoglobins - analysis
Humans
Infant, Newborn
Iron - therapeutic use
Phosphates - therapeutic use
Pregnancy
Prospective Studies
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Summary:Iron deficiency anemia is a very common health problem during pregnancy and intravenous (IV) iron substitution has become part of routine management. However, recent studies have raised concerns about the association of IV iron infusion and the development of secondary transitory hypophosphatemia (HP) in adults, including pregnant women. We aimed to evaluate the impact of IV iron administration during pregnancy on the phosphocalcic metabolism of newborns. A prospective, single-center, observational study was performed from December 2022 to May 2023 at the maternity facility of Geneva University Hospitals. We included women treated with either IV or oral iron during pregnancy. At delivery, a maternal blood sample was collected to assess hemoglobin, hematocrit, and levels of ferritin, phosphate and calcium, as well as an umbilical cord blood sample to assess levels of phosphate and calcium. Univariate and multivariate analyses were performed to evaluate the contribution of IV iron substitution on cord blood phosphatemia and calcemia, considering potential confounding factors. Neonatal HP was defined as a phosphate level
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2024.2320671