Sleep deprivation in early life: Cellular and behavioral impacts

• Published in: Neuroscience and biobehavioral reviews 2024-04, Vol.159, p.105597-105597, Article 105597
• Main Authors: Dalferth, Thais F., Nunes, Magda L., Furini, Cristiane R.G.
• Format: Article
• Language: English
• Subjects: Animals; Attention; Cognitive and behavioral impacts; Cognitive Dysfunction; Endocrine function; Metabolic changes; Molecular physiology; Neurodevelopmental processes; Prolonged wakefulness; Sleep; Sleep Deprivation; Sleep deprivation in animals; Stress in early life; Wakefulness - physiology
• ISSN: 0149-7634; 1873-7528
• DOI: 10.1016/j.neubiorev.2024.105597

Sleep deprivation has become increasingly prevalent in contemporary society, and the consequences of this reality such as cognitive impairment and metabolic disorders, are widely investigated in the scientific scenario. However, the impact of sleep deprivation on the health of future generations is a challenge, and researchers are focusing their attention on this issue. Thus, this review aims to describe the impact of sleep deprivation in early life in animal models, particularly rodents, discussing the molecular physiology impacted by prolonged wakefulness in early life, as well as the changes that interfere with neurodevelopmental processes. Additionally, it explores the changes impacting metabolic mechanisms and discusses both the short- and long-term consequences of these processes on endocrine, behavioral, and cognitive functions. Finally, we briefly address some strategies to mitigate the adverse effects of sleep deprivation. [Display omitted] •SDEL contributes to disruptions in the homeostasis of the animal organism.•The molecular changes induced by SDEL contribute to cognitive and behavioral disorders.•SDEL contributes to metabolic imbalance, which leads to developmental deficiencies.•There are alternatives that can help mitigate the damage caused by sleep deprivation.