Prevalence and Predictors of Celiac Disease in Children With Constipation

Objectives To determine the prevalence of celiac disease and its predictors in children with constipation. Methods A hospital-based cross-sectional comparative study was conducted between November, 2018 to April, 2020. Children aged 1–12 years were screened for the presence of constipation as per RO...

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Bibliographic Details
Published in:Indian pediatrics 2024-04, Vol.61 (4), p.331-336
Main Authors: Meena, Monika, Narang, Manish, Meena, Rajesh Kumar, Aggarwal, Anju
Format: Article
Language:English
Subjects:
Autoantibodies
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - epidemiology
Child
Constipation - epidemiology
Cross-Sectional Studies
Humans
Immunoglobulin A
Maternal and Child Health
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Prevalence
Transglutaminases
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Summary:Objectives To determine the prevalence of celiac disease and its predictors in children with constipation. Methods A hospital-based cross-sectional comparative study was conducted between November, 2018 to April, 2020. Children aged 1–12 years were screened for the presence of constipation as per ROME IV criteria and designated as cases. Age and sex matched healthy children with normal bowel habits were enrolled as comparison group. Participants underwent a detailed history and examination, and were screened for celiac disease by estimating serum anti-tissue transglutaminase IgA antibody levels (tTG-IgA). Upper gastrointestinal endoscopy and duodenal biopsy were performed in all participants who tested positive on screening (serum tTG-IgA ≥ 20 U/mL). The prevalence of celiac disease and associated factors were compared between the two groups. Results A total of 460 children (230 in each group) with mean (SD) age 64.08 (37.12) months were enrolled. Twenty-one (4.6%) children screened positive for anti tTG antibodies, among these 15 (75%) children had biopsy features suggestive of celiac disease (Marsh grade III). Children with constipation had significantly higher prevalence of celiac disease (5.65% vs 0.87%, P = 0.004) compared to children without constipation. Wasting and stunting were significantly associated with celiac disease in constipated children ( P < 0.001). Conclusion Children with constipation and associated growth failure have a high prevalence of celiac disease.
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-024-3154-8