Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients

What are the clinical pregnancy and live birth rates in women who underwent up to two more euploid blastocyst transfers after three failures in the absence of another known factor that affects implantation? The fourth and fifth euploid blastocyst transfers resulted in similar live birth rates of 40%...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2024-05, Vol.39 (5), p.974-980
Main Authors: Gill, Pavan, Ata, Baris, Arnanz, Ana, Cimadomo, Danilo, Vaiarelli, Alberto, Fatemi, Human M, Ubaldi, Filippo Maria, Garcia-Velasco, Juan A, Seli, Emre
Format: Article
Language:English
Subjects:
Adult
Birth Rate
Blastocyst
Embryo Implantation
Embryo Transfer - methods
Embryo Transfer - statistics & numerical data
Female
Fertilization in Vitro - methods
Fertilization in Vitro - statistics & numerical data
Humans
Live Birth
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Rate
Prevalence
Retrospective Studies
Treatment Failure
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Summary:What are the clinical pregnancy and live birth rates in women who underwent up to two more euploid blastocyst transfers after three failures in the absence of another known factor that affects implantation? The fourth and fifth euploid blastocyst transfers resulted in similar live birth rates of 40% and 53.3%, respectively, culminating in a cumulative live birth rate of 98.1% (95% CI = 96.5-99.6%) after five euploid blastocyst transfers. The first three euploid blastocysts have similar implantation and live birth rates and provide a cumulative live birth rate of 92.6%. An international multi-center retrospective study was conducted at 25 individual clinics. The study period spanned between January 2012 and December 2022. A total of 123 987 patients with a total of 64 572 euploid blastocyst transfers were screened for inclusion. Patients with a history of any embryo transfer at another clinic, history of any unscreened embryo transfer at participating clinics, parental karyotype abnormalities, the use of donor oocytes or a gestational carrier, untreated intracavitary uterine pathology (e.g. polyp, leiomyoma), congenital uterine anomalies, adenomyosis, communicating hydrosalpinx, endometrial thickness
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deae040