Impact of Baseline Anxiety on Well-being in People with Post-COVID-19 Condition: A Secondary Analysis

Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety's association w...

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Bibliographic Details
Published in:CNS spectrums 2024-04, Vol.29 (2), p.150-154
Main Authors: Kleine, Nicholas, Kwan, Angela T.H., Le, Gia Han, Guo, Ziji, Phan, Lee, Subramaniapillai, Mehala, McIntyre, Roger S.
Format: Article
Language:English
Subjects:
Clinical trials
COVID-19
Education
Employment
Generalized anxiety disorder
Generalized linear models
Infections
Long COVID
Mental depression
Mental health
Original Research
Severe acute respiratory syndrome coronavirus 2
Well being
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Summary:Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety's association with measures of well-being in people with PCC. This is a post hoc analysis utilizing data from a placebo-controlled, randomized, double-blind clinical trial assessing the effect of vortioxetine on cognitive impairment in individuals with PCC (NCT05047952). Baseline data with respect to anxiety and well-being were collected using the Generalized Anxiety Disorder Scale, 7-Item (GAD-7), and the World Health Organization (WHO) Well-Being Index, 5-Item (WHO-5), respectively. A generalized linear model (GLM) analysis on baseline GAD-7 and WHO-5 scores was conducted with age, sex, employment status, education level, previous major depressive disorder (MDD) diagnosis, and confirmed COVID-19 cases as covariates. Data was analyzed in a sample of 144 participants (  = 144). After controlling for the aforementioned covariates, the results found that GAD-7 and WHO-5 scores had a significant negative correlation (β = -0.053,  = 
ISSN:1092-8529
2165-6509
DOI:10.1017/S1092852924000099