Effect of MAOA rs1465108 polymorphism on susceptibility to substance/alcohol use disorder: a novel PCR-RFLP assay for the detection of MAOA rs1465108

Background The health and social consequences of substance/alcohol use disorders are harmful. Most of the individuals cannot stop using them due to more likely their genetic background. The current study aimed both to develop a novel PCR-RFLP method for genotyping of MAOA rs1465108 and to analyze th...

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Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.400-400, Article 400
Main Authors: Kaya-Akyüzlü, Dilek, Özkan-Kotiloğlu, Selin, Yıldırım, Sariye Aybüke, Danışman, Mustafa, Yıldırım, Mukaddes Asena, Özgür-İlhan, İnci
Format: Article
Language:English
Subjects:
Alcohol use
Animal Anatomy
Animal Biochemistry
Anxiety
Biomedical and Life Sciences
Genotyping
Histology
Life Sciences
Mental depression
Methamphetamine
Morphology
Narcotics
Opioids
Original Article
Polymerase chain reaction
Polymorphism
Restriction fragment length polymorphism
Statistical analysis
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Summary:Background The health and social consequences of substance/alcohol use disorders are harmful. Most of the individuals cannot stop using them due to more likely their genetic background. The current study aimed both to develop a novel PCR-RFLP method for genotyping of MAOA rs1465108 and to analyze the effect of MAOA rs1465108 on the risk of alcohol (AUD), opioid (OUD) or methamphetamine (MUD) use disorders and on the depressive and anxiety symptoms in a Turkish population. Methods and results A total of 353 individual with AUD ( n  = 154), OUD ( n  = 160) or MUD ( n  = 39) and 109 healthy subjects were included. The intensity of anxiety and depressive symptoms and craving and opioid withdrawal were measured by appropriate scales. Logistic regression analysis revealed no association between MAOA rs1465108 polymorphism and substance/alcohol use disorder ( p  > 0.05). Healthy subjects (3.0) had significantly lower levels of depressive symptoms than individuals with OUD (27.0), AUD (21.0) and MUD (25.5) groups. The severity of depressive symptoms was significantly higher in OUD as compared to AUD. There was a statistically significant difference between individuals with AUD, OUD and MUD in view of the average ages of first use (17, 19 and 20 years, respectively) ( p  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09366-z