Evaluation of Tpeak-end interval, Tpeak-end/QT, and Tpeak-end/Qtc ratio during acute migraine attack in the emergency department

• Published in: Acta neurologica Belgica 2024-06, Vol.124 (3), p.949-955
• Main Authors: Selvi, Fatih, Korkut, Mustafa, Bedel, Cihan, Kuş, Görkem, Zortuk, Ökkeş
• Format: Article
• Language: English
• Subjects: Adult; Arrhythmias, Cardiac - physiopathology; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Electrocardiography - methods; Emergency Service, Hospital; Female; Humans; Male; Medicine/Public Health; Middle Aged; Migraine Disorders - physiopathology; Neurology; Neuroradiology; Neurosciences; Original Article; Prospective Studies
• ISSN: 0300-9009; 2240-2993
• DOI: 10.1007/s13760-024-02497-x

Introduction During an acute migraine attack, changes in ventricular repolarisation parameters may occur due to an imbalance in the autonomic nervous system. Tpeak-tend (Tp-e) interval, Tp-e/QT ratio, and Tp-e/corrected QT (QTc) ratio are novel parameters of arrhythmogenesis and can be easily calculated in electrocardiography (ECG). The objective of this study is to demonstrate that novel ventricular repolarisation parameters can anticipate the risk of ventricular dysrhythmia in the migraine attack period. Methods This research was a prospective case–control study, which recruited a total of 144 participants, including 74 migraine patients and 70 healthy volunteers in the control group (CG) who met the criteria for migraine with or without aura. All participants underwent 12-lead ECG recordings, and the study compared the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio with those of the CG. Results The average age of patients experiencing migraine attacks was 38.14 ± 10.82, with 58 (76%) of these patients being female. The Tp-e interval mean was higher in the migraine attack group than the CG, with a statistically significant difference discovered (74.22 ± 20.20 ms [ms] compared to 65.39 ± 11.33 ms, p  = 0.001). However, there were higher mean Tp-e/QT and Tp-e/QTc ratios in the migraine attack group compared to the CG, and this difference was found to be statistically significant (0.20 ± 0.05 vs. 0.17 ± 0.03, p  = 0.001, 0.18 ± 0.52 vs 0.16 ± 0.29, p  = 0.003, respectively). Conclusion Prolonged Tp-e interval and elevated Tp-e/QT and Tp-e/QTc ratios were observed in migraine patients who presented to the emergency department, indicating a potential risk of ventricular dysrhythmia.