Association of long noncoding RNA H19 rs2839698 C/T with hepatitis B virus infection and hepatocellular carcinoma risk

The intricate pathogenesis of the hepatitis B virus (HBV) and its progression to hepatocellular carcinoma (HCC) have not yet been fully elucidated. H19 is one of the earliest imprinted long noncoding RNAs (lncRNAs) associated with liver pathobiology. This study investigated the association of H19 si...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2024-04, Vol.38 (4), p.e23673-n/a
Main Authors: Motawi, Tarek K., Mady, Amira E., Elhelbawy, Mostafa, Talaat, Roba M., Shahin, Nancy N.
Format: Article
Language:English
Subjects:
Cirrhosis
Genetic diversity
Genotyping
H19
HBV
HCC
Hepatitis
Hepatitis B
Hepatocellular carcinoma
Infections
Liver cancer
LncRNA
Non-coding RNA
Nucleotides
Pathogenesis
Polymerase chain reaction
Single-nucleotide polymorphism
SNP
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The intricate pathogenesis of the hepatitis B virus (HBV) and its progression to hepatocellular carcinoma (HCC) have not yet been fully elucidated. H19 is one of the earliest imprinted long noncoding RNAs (lncRNAs) associated with liver pathobiology. This study investigated the association of H19 single nucleotide polymorphisms (SNPs) rs2839698 C/T and rs217727 C/T with HBV and HBV‐related HCC and their correlation with H19 expression level. A total of 230 subjects were enrolled in this study including 100 HBV‐infected patients, 30 HBV‐related HCC patients, and 100 apparently healthy controls. TaqMan genotyping human assays were utilized to assess allelic discrimination for H19 SNPs. H19 expression was assessed using quantitative real‐time polymerase chain reaction (qRT‐PCR). Our findings showed that H19 rs2839698 was linked to a higher incidence of HBV infection and HBV‐related HCC. Individuals who bear the CT genotype of rs2839698 were more susceptible to HBV infection (OR = 3.05; 95% CI 1.714–5.457; p 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23673