Study on the electrochemical behaviour of the anticancer herbal drug emodin

The electrochemical behaviour of the anticancer herbal drug emodin was investigated by cyclic voltammetry (CV) at glassy carbon electrode. In 0.05 M NH 3-NH 4Cl (50% ethanol, pH 7.2) buffer solution, a pair of quasi-reversible redox peaks at potentials of E p1 = −0.688 V and E p2 = −0.628 V and one...

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Bibliographic Details
Published in:Electrochimica acta 2006-08, Vol.51 (26), p.5961-5965
Main Authors: Wang, Liping, Zhang, Zongpei, Ye, Baoxian
Format: Article
Language:English
Subjects:
Anticancer herbal drug
Antineoplastic agents
Biological and medical sciences
Determination
Dynamics parameters
Electrochemical
Emodin
General aspects
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
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Summary:The electrochemical behaviour of the anticancer herbal drug emodin was investigated by cyclic voltammetry (CV) at glassy carbon electrode. In 0.05 M NH 3-NH 4Cl (50% ethanol, pH 7.2) buffer solution, a pair of quasi-reversible redox peaks at potentials of E p1 = −0.688 V and E p2 = −0.628 V and one irreversible anodic peak, which was a typical anodic peak of emodin, at E p3 = −0.235 V appeared at a scan rate of 100 mV/s. The irreversible anodic peak currents are linearly related to the emodin concentrations in a range from 8.9 × 10 −8 M to 7.8 × 10 −6 M with a pre-concentration time of 80 s under −0.620 V. Using the established method without pretreatment and pre-separation, emodin in herbal drug was determined with satisfactory results. Moreover, the electrode process dynamics parameters were also investigated by electrochemical techniques.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2006.03.082