A comprehensive and flexible approach to the automated-dissolution testing of pharmaceutical drug products incorporating direct UV-vis fiber-optic analysis, on-line fluorescence analysis, and off-line storage options

An automated system for on‐line determination of the dissolution rates of drug‐delivery formulations to USP Methods I and II is described. The system employs UV–vis spectroscopy utilizing either a fiber‐optic probe for direct determination or the option of on‐line flow through analysis with prior fi...

Full description

Saved in:
Bibliographic Details
Published in:Laboratory robotics and automation 2000, Vol.12 (1), p.12-22
Main Authors: Rogers, P., Hailey, P. A., Johnson, G. A., Dight, V. A., Read, C., Shingler, A., Savage, P., Roche, T., Mondry, J.
Format: Article
Language:English
Subjects:
Automation
Database systems
Dissolution
Fiber optics
Filtration
Fluorescence
Information technology
Ultraviolet spectroscopy
User interfaces
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An automated system for on‐line determination of the dissolution rates of drug‐delivery formulations to USP Methods I and II is described. The system employs UV–vis spectroscopy utilizing either a fiber‐optic probe for direct determination or the option of on‐line flow through analysis with prior filtration. The system is also capable of on‐line flow through analysis utilizing both UV–vis and fluorescence detection and an off‐line storage option for further sample processing. The system also comprises a complete IT solution including a simple user interface, data archival to an NT server, remote client server interrogation of the database, and automatic report generation. © 2000 John Wiley & Sons, Inc. Lab Robotics and Automation 12:12–22, 2000
ISSN:0895-7533
1098-2728
DOI:10.1002/(SICI)1098-2728(2000)12:1<12::AID-LRA3>3.0.CO;2-F